An insect bite may result in inflammation of that spot. This is
triggered by the alarm chemicals such as

Options

A. histamine and dopamine
B. histamine and kinins
C. interferons and opsonin
D. interferons and histones.

Answer

B

Explanation

Inflammation is common to almost all diseases that involve microbiologic, chemical, or physical injury to living tissues. Acute inflammation may be defined as the microcirulation response to injury, the cardinal signs area heat, redness, pain, swelling, and loss of function. The accompanying microcirculatory changes comprise arteriolar vasodilation, increased small vein permeability, formation of edema fluid, and WBC migration to the site of injury. Histamine is stored in masat cell granules and basophils and is relased by inflammatory and immunologic stimuli. It plays an important role in acute inflammation, oxerting a dilator action on arterioles, increasing the permeability of small venules to plasma proteins and causing pain by stimulating nociceptors. However, the generally poor clinical efficacy of anthistamines suggests that their role nonimmune inflammation is limited. Plasma kinins such as baradykinin are not stored but are released by the action of kininogenase on plasma `a_(2).`-globulin. Bradykinin is a potent vasodilator, increasing small vein permeability and causing pain b stimulating peripheral nociceptors, but it has a short half-life.