Symptoms of malaria in spleen and skin are due to

Options

A. Schuffner's granules
B. Hemozoin
C. Haematin
D. Blood suger.

Answer

To answer the question regarding the symptoms of malaria in the spleen and skin, we need to analyze the options provided and understand the role of hemozoin in the context of malaria.

### Step-by-Step Solution:

1. **Understanding Malaria**: Malaria is caused by the Plasmodium parasite, which infects red blood cells (RBCs) in humans. The symptoms of malaria are largely due to the body's response to the infection and the byproducts produced by the parasite.

2. **Role of Hemoglobin**: The Plasmodium parasite feeds on hemoglobin in the RBCs. During this process, it breaks down hemoglobin to access the nutrients it needs for survival and reproduction.

3. **Formation of Hemozoin**: As the parasite digests hemoglobin, it releases heme, which is a toxic byproduct. To detoxify this heme, the parasite converts it into a less harmful form known as hemozoin. This process is crucial for the survival of the parasite within the host.

4. **Location of Hemozoin Accumulation**: Hemozoin accumulates in macrophages, which are immune cells that engulf and digest cellular debris and pathogens. The primary locations where these macrophages can be found include the spleen, liver, and bone marrow. This accumulation is what leads to the symptoms observed in these organs.

5. **Symptoms in Spleen and Skin**: The presence of hemozoin in the spleen contributes to splenomegaly (enlargement of the spleen), while its effects on the skin can lead to symptoms such as pallor or jaundice due to the breakdown of red blood cells and the release of bilirubin.

6. **Conclusion**: Given the above points, the symptoms of malaria in the spleen and skin are primarily due to hemozoin, which is the correct answer to the question.

### Final Answer:
The symptoms of malaria in the spleen and skin are due to **hemozoin**.

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