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Sickle cell anaemia is more common in So...

Sickle cell anaemia is more common in South Africa. This is due to

A

Change in beta-chain of haemoglobin

B

More population of house flies

C

Change in alpha-chain of haemoglobin

D

Change in gamma-chain of haemoglobin

Text Solution

Verified by Experts

The correct Answer is:
A
(a) Sickle cell aneamia is caused by a single gene mutation in the sixth place of `beta` - chain of haemoglobin where glutamic acid is replaced by valine.
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Knowledge Check

  • Sickle cell anaemia is due to

    A
    Transition / Base substitution /Point mutation
    B
    Transversion / Base substitution /Point mutation
    C
    Transition / Base substitution / Frameshift mutation
    D
    Transversion / Base substitution / Frameshift mutation

  • Sickle cell anaemia is example of

    A
    sex-linked inheritance
    B
    deficiency disease
    C
    autosomal heritable disease
    D
    infectious disease

  • In sickle cell anaemia-

    A
    The mutant haemoglobin molecule undergoes polymerisation under low oxygen tension causing the change in the shape of RBC
    B
    Substitution of Glutamic acid by valine at the sixth position of the `alpha-`chain of haemoglobin
    C
    The mutant hamoglobin undergoes polymerization under high oxygen tension causing the chage in shape of RBC
    D
    `alpha-`globin chain is modified

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