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How are prosthetic groups different from...

How are prosthetic groups different from co-factors?

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Prosthetic groups are organic compound that are tightly bound to the apoenzyme, (an enzyme without cofaetor) by covalent or non-covalent forces, e.g., in peroxidase and catalase, which catalyse the breakdown of hydrogen peroxide to water and oxygen, haeme is the prosthetic group and it is a part of the active site of the enzyme.
Co-factor is small, heat stable and non-protein part of conjugate enzyme. It may be inorganic or organic in nature. Co-factors when loosely bound to a enzyme is called coenzyme and when tightly bound to apoenzyme is called prosthetic group.
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Knowledge Check

  • Prosthetic groups differ from co-factors in that the former is

    A
    tightly bound to the coenzyme
    B
    tightly bound to the apoenzyme
    C
    loosely bound to the inorganic catalyst
    D
    tightly bound to the active site
  • The prosthetic group is present in

    A
    Simple proteins
    B
    derived proteins
    C
    conjugated proteins
    D
    all proteins
  • Prosthetic group is present in

    A
    simple protein
    B
    conjugated protein
    C
    vitamins
    D
    hormones
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