A : Glucose and Mannose are Anomers.
R : Configuration at 1st carbon differ in Gluco& and Mannose.

Options

A. If both Assertion and Reason are true and the reason is the correct explanation of the assertion, then mark (1).
B. If both Assertion and Reason are true but the reason is not the correct explanation of the assertion, then mark (2).
C. If Assertion is true statement but Reason is false, then mark (3).
D. If both Assertion and Reason are false statements, then mark (4).

Answer

To solve the question, we need to analyze both the assertion (A) and the reason (R) provided:

**Assertion (A):** Glucose and Mannose are Anomers.
**Reason (R):** Configuration at 1st carbon differs in Glucose and Mannose.

### Step-by-Step Solution:

1. **Understanding Anomers:**
- Anomers are a type of stereoisomer found in carbohydrates. They differ in configuration at the anomeric carbon (the carbon that was part of the carbonyl group in the open-chain form of the sugar).

2. **Identifying the Structures of Glucose and Mannose:**
- Glucose and Mannose are both hexoses (six-carbon sugars) and can exist in cyclic forms.
- In their cyclic forms, both sugars have a ring structure where the first carbon (C1) is the anomeric carbon.

3. **Analyzing the Configuration:**
- In the cyclic form of glucose, the hydroxyl group (-OH) on the anomeric carbon (C1) can be either on the right (α-D-glucose) or on the left (β-D-glucose).
- In mannose, the configuration at C1 is also similar, but the configurations at other carbons differ.

4. **Comparing the Two Sugars:**
- The key difference between glucose and mannose lies in the configuration at the second carbon (C2), not the first carbon (C1).
- Therefore, while glucose and mannose are indeed stereoisomers, they are classified as epimers (specifically, they differ at C2), not anomers.

5. **Conclusion:**
- Since the assertion states that glucose and mannose are anomers, which is incorrect, and the reason states that the configuration at the first carbon differs, which is also incorrect, both the assertion (A) and the reason (R) are false.

### Final Answer:
Both the assertion (A) and the reason (R) are false.