Define denaturation of enzymes .

Explanation

**Step-by-Step Solution:**

1. **Definition of Denaturation**: Denaturation of enzymes refers to the process where the molecular structure of an enzyme (which is primarily a protein) is altered, leading to a loss of its functional activity.

2. **Molecular Structure Changes**: Enzymes have a specific three-dimensional structure that is crucial for their function. When denaturation occurs, this structure is modified, which can affect the enzyme's active site—the region where substrate molecules bind.

3. **Loss of Activity**: Due to the changes in the molecular structure, the enzyme can no longer perform its catalytic function. This means that the enzyme is rendered inactive and cannot facilitate biochemical reactions as it normally would.

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