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Williamson's synthesis is a convenient m...

Williamson's synthesis is a convenient method used to prepare both symmetrical and unsymmetrical ethers.
What are the starting materials required to prepare anisole by Williamson's synthesis?

Answer

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Knowledge Check

  • An important route to unsymmetrical ethers is a nucleophilic substitution reaction known as the Williamson synthesis. This synthesis consists of an S_(N)2 reaction of a sodium alkoxide with an alkyl halide, alkyl sulphonate or alkyl sulphate. By a proper choice of reagents, both symmetrical and unsymmetrical ethers can be prepared by Williamson synthesis. The reverse process of cleavage of ethers to give back the original alkyl halide and the alcohol can be carried out by heating the ether with HI at 373 K. Which of the following ethers cannot be prepared by Williamson synthesis?

    A
    Methoxybenzene
    B
    Benzyl p-nitrophenyl ether
    C
    tert-Butyl methyl ether
    D
    Di-ether-butyl ether
  • An important route to unsymmetrical ethers is a nucleophilic substitution reaction known as the Williamson synthesis. This synthesis consists of an S_(N)2 reaction of a sodium alkoxide with an alkyl halide, alkyl sulphonate or alkyl sulphate. By a proper choice of reagents, both symmetrical and unsymmetrical ethers can be prepared by Williamson synthesis. The reverse process of cleavage of ethers to give back the original alkyl halide and the alcohol can be carried out by heating the ether with HI at 373 K. Benzyl ethyl ether reacts with HI to form

    A
    p-iodotoulene and ethyl alcohol
    B
    benzyl alcohol and ethyl iodide
    C
    phenol and ethyl iodide
    D
    iodobenzene and ethyl alcohol
  • An important route to unsymmetrical ethers is a nucleophilic substitution reaction known as the Williamson synthesis. This synthesis consists of an S_(N)2 reaction of a sodium alkoxide with an alkyl halide, alkyl sulphonate or alkyl sulphate. By a proper choice of reagents, both symmetrical and unsymmetrical ethers can be prepared by Williamson synthesis. The reverse process of cleavage of ethers to give back the original alkyl halide and the alcohol can be carried out by heating the ether with HI at 373 K. Which of the following reagents when heated will give a good yield of ether?

    A
    Isopropyl bromide and sodium isopropoxide
    B
    Isopropyl bromide and sodium ethoxide
    C
    Bromobenzene and sodium phenoxide
    D
    Sodium tert-butoxide and ethyl bromide
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