Reaction of ammonia derivative with carbonyl compound is an example of -

Options

A. Addition and Substitution
B. Substitution and Elimination
C. Addition and Elimination
D. Addition and intramolecular substitution

Answer

To solve the question regarding the reaction of an ammonia derivative with a carbonyl compound, we can break it down into a step-by-step explanation.

### Step-by-Step Solution:

1. **Identify the Reactants**:
We will consider the reaction between acetaldehyde (CH3CHO) and hydroxylamine (NH2OH), which is an ammonia derivative.

**Hint**: Look for common ammonia derivatives that can react with carbonyl compounds.

2. **Nucleophilic Attack**:
The nitrogen atom in hydroxylamine has a lone pair of electrons. This lone pair attacks the carbonyl carbon of acetaldehyde. As a result, the double bond between carbon and oxygen in the carbonyl group shifts, leading to the formation of a tetrahedral intermediate.

**Hint**: Remember that nucleophiles attack electrophilic centers, such as the carbonyl carbon.

3. **Formation of Tetrahedral Intermediate**:
After the nucleophilic attack, we have a tetrahedral intermediate where the carbon is now bonded to the nitrogen from hydroxylamine and has a negative charge on the oxygen.

**Hint**: Visualize the structure of the tetrahedral intermediate to understand the bonding changes.

4. **Proton Transfer**:
The negatively charged oxygen can now remove a proton (H+) from the nitrogen, leading to a new structure where nitrogen is positively charged, and oxygen is neutral.

**Hint**: Proton transfer is a common step in reactions involving acids and bases.

5. **Elimination of Water**:
The next step involves the elimination of water (H2O) from the intermediate. This occurs when the hydroxyl group (OH) on the nitrogen and a hydrogen atom from the carbon are removed, resulting in the formation of an imine.

**Hint**: Elimination reactions often involve the removal of small molecules like water.

6. **Final Product**:
The final product of this reaction is an imine (specifically, an oxime in this case), which is formed from the reaction of hydroxylamine with acetaldehyde.

**Hint**: Check the structure of the final product to confirm it matches the expected outcome of the reaction.

7. **Conclusion**:
The overall reaction of an ammonia derivative (hydroxylamine) with a carbonyl compound (acetaldehyde) is an example of a nucleophilic addition followed by elimination, leading to the formation of an imine.

**Hint**: Remember that this type of reaction is characteristic of carbonyl compounds reacting with nucleophiles.

### Final Answer:
The reaction of an ammonia derivative with a carbonyl compound is an example of a **nucleophilic addition-elimination reaction**.