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The predominant form of histamine presen...

The predominant form of histamine present in human blood is (`pK_(a)` , Histidine=6.0)

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To determine the predominant form of histamine present in human blood, we need to analyze the pKa values and the pH of the blood. ### Step-by-Step Solution: 1. **Identify the pKa Values**: - The pKa value of the imidazole nitrogen in histidine is given as 6.0. - The pKa value of the amino group (NH2) is given as 9.7. 2. **Know the pH of Human Blood**: - The pH of human blood is approximately 7.4. 3. **Compare pH with pKa Values**: - The pH of blood (7.4) is higher than the pKa of the imidazole nitrogen (6.0). According to the Henderson-Hasselbalch equation, when the pH is greater than the pKa, the predominant form is deprotonated. - The pH of blood (7.4) is lower than the pKa of the amino group (9.7). This means that the amino group will be protonated at this pH. 4. **Determine the Predominant Form of Histamine**: - Since the imidazole nitrogen (pKa = 6.0) will be deprotonated at pH 7.4, it will be in its neutral form. - The amino group (NH2) will be protonated at pH 7.4, resulting in the NH3+ form. 5. **Conclusion**: - Therefore, the predominant form of histamine in human blood will have a protonated amino group (NH3+) and a neutral imidazole nitrogen. ### Final Structure: The structure of histamine in its predominant form in human blood can be represented as follows: - A protonated amino group (NH3+) at one end. - A neutral imidazole ring.
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