Peptides are formed by the joining of am...

Peptides are formed by the joining of amino acids through amide linkage. Which of the following statement is not true in this respect?

Amide group are more resistent to hydrolysis than one similar ester groups

`p-pi` resonance stabilizes the amides bond

Stable conformation of peptides are restricted to those having planer amide groups

Amide groups do not participate in hydrogen bonding interaction

Text Solution

AI Generated Solution

The correct Answer is:

To determine which statement regarding peptides and amide linkages is not true, we will analyze each statement one by one. ### Step-by-Step Solution: 1. **Understanding Peptides and Amide Linkage**: - Peptides are formed by the joining of amino acids through amide linkages (also known as peptide bonds). - An amide bond is characterized by a carbonyl group (C=O) directly attached to a nitrogen atom (N). 2. **Evaluating Each Statement**: - **Statement 1**: "Amide groups are more resistant to hydrolysis than similar ester groups." - This statement is **true**. Amides are less reactive towards hydrolysis compared to esters due to resonance stabilization, which makes the carbonyl carbon less electrophilic. - **Statement 2**: "P-Pi resonance stabilizes the amide bond." - This statement is also **true**. The resonance between the nitrogen and the carbonyl oxygen in the amide bond contributes to its stability. - **Statement 3**: "Stable conformation of peptides are restricted to those having planar amide groups." - This statement is **true**. The amide bond has a partial double bond character due to resonance, which restricts rotation and results in a planar configuration. - **Statement 4**: "Amide groups do not participate in hydrogen bonding interaction." - This statement is **not true**. Amide groups can participate in hydrogen bonding due to the presence of a hydrogen atom bonded to the nitrogen, which can interact with electronegative atoms (like oxygen) in other molecules. 3. **Conclusion**: - The statement that is not true is **Statement 4**: "Amide groups do not participate in hydrogen bonding interaction." ### Final Answer: The statement that is not true is: **"Amide groups do not participate in hydrogen bonding interaction."** ---

Topper's Solved these Questions

BIOMOLECULES
AAKASH INSTITUTE ENGLISH|Exercise Section-C (Objective Type Questions (More than one option is correct))|10 Videos
BIOMOLECULES
AAKASH INSTITUTE ENGLISH|Exercise Section-D (Comprehension Questions )|9 Videos
BIOMOLECULES
AAKASH INSTITUTE ENGLISH|Exercise Objective type question(Objective Type Questions (One option is correct))|5 Videos
AMINES
AAKASH INSTITUTE ENGLISH|Exercise Assignment Section -J (Aakash Challengers Questions)|9 Videos
CHEMICAL BONDING AND MOLECULAR STRUCTURE
AAKASH INSTITUTE ENGLISH|Exercise Assignment Section J (Aakash Challengers Questions)|10 Videos

Which of the following statements is true with respect to Growth:

It stops when maturity has been attained.

Is continuous throughout life.

Is a progressive series of changes.

Cannot be measured

Which of the following statements about amino acids is incorrect ?

Essential amino acids are not synthesised in the body, therfore have to be provided in the diet.

Leucine, isoleucine, lysine, valine are essential amino acids.

Cysteine and methionine are sulphur containing amino acids.

Lysine and arginine are acidic amino acids.

Which of the following statements about amino acids is false

They are constituents of all proteins

Alanine having one amino and one carboxylic group.

Most naturally occuring amino acids have D-configuration.

Glycine is the only naturally occuring amino acid which is optically inactive.