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Statement-1. Cimetidine is an antacid. ...

Statement-1. Cimetidine is an antacid.
Statement-2. It prevents the interaction of histamine thereby producing less hydrochloric acid in the stomach.

A

Statement-1 is True, Statement-2 is True , Statement-2 is the correct explanation for statement 1

B

Statement-1 is True, Statement-2 is True , Statement-2 is not a correct explanation for statement 1

C

Statement-1 is True, Statement-2 is False

D

Statement-1 is False, Statement-2 is True.

Text Solution

AI Generated Solution

The correct Answer is:
To analyze the statements provided in the question, we will break down the information step by step. ### Step-by-Step Solution: 1. **Understanding Cimetidine**: - Cimetidine is a medication that is classified as an H2 (histamine-2) receptor antagonist. It is primarily used to reduce stomach acid production. 2. **Evaluating Statement-1**: - The first statement claims that "Cimetidine is an antacid." - This statement is **correct** because Cimetidine is indeed used to treat conditions related to excess stomach acid, such as peptic ulcers and gastroesophageal reflux disease (GERD). 3. **Evaluating Statement-2**: - The second statement claims that "It prevents the interaction of histamine thereby producing less hydrochloric acid in the stomach." - This statement is also **correct**. Cimetidine works by blocking H2 receptors in the stomach lining, which inhibits the action of histamine. Histamine normally stimulates the secretion of hydrochloric acid (HCl) in the stomach. By blocking this interaction, Cimetidine effectively reduces the amount of HCl produced. 4. **Conclusion**: - Both statements are correct, and Statement-2 provides a valid explanation for Statement-1. Therefore, the correct answer is that both statements are true, and Statement-2 is the correct explanation of Statement-1. ### Final Answer: Both Statement-1 and Statement-2 are correct, and Statement-2 is the correct explanation for Statement-1. ---
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Over production of acid in the stomach causes irritation and pain. In severe cases, ulcers are developed in the stomach. Until 1970, only treatment for acidity was administration of antacids, such as sodium hydrogencarbonate or a mixture of aluminium and magnesium hydroxide. However, excessive hydrogencarbonate can make the stomach alkaline and trigger the production of even more acid. Metal hydroxides are better alternatives because of being insoluble, these do not increase the pH above neutrality. These treatments control only symptoms, and not the cause. Therefore, with these metal salts, the patients cannot be treated easily. In advanced stages, ulcers become life threatening and its only treatment is removal of the affected part of the stomach. A major breakthrough in the treatment of hyperacidity came through the discovery according to which a chemical, histamine stimulates the secretion of pepsin and hydrochloric acid in the stomach. The drug cimetidine (Tegamet), was designed to prevent the interaction of histamine with the receptors present in the stomach wall. This resulted in release of lesser amount of acid. The importance of the drug was so much that it remained the largest selling drug in the world until another drug, ranitidine (Zantac), was discovered. Which of the two treatments to heal acidity, hydrogencarbonate and metal hydroxide, is better and why ?

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Knowledge Check

  • Which of the following antacids prevent the release of hydrochloric acid from the stomach wall

    A
    Renitidine
    B
    Cimetidine
    C
    omeprazole
    D
    All the three
  • Which of the following antacids prevent the release of hydrochloric acid from the stomach wall?

    A
    Ranitidine
    B
    Cimetidine
    C
    Omeprazole
    D
    All of these
  • Which of the following antacids prevent the release of hydrochloric acid from the stomach wall?

    A
    Ranitidine
    B
    Cimetidine
    C
    Omeprazole
    D
    All of these
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