Human Health and Diseases

• Health, for a long time, was considered as a state of body and mind where there was a balance of certain ‘humors. 
• According to the World Health Organization (WHO), The complete social, emotional, and psychological well-being of a person is called health.

1.0Factors affecting health

Mental state, genetic disorders, infections and life style (habits, rest and exercise

2.0What is the Definition of Health?

• As per 'Good humor' hypothesis arrived at by reflective thought and asserted by Hippocrates along with Indian Ayurveda System. 1 Health is a state of body and mind where there was a balance of certain 'humors' e.g., persons with black bile belonged to hot personality and had fevers
• Mind influences our immune system through neural and endocrine systems, and that our immune system maintains our health i.e., state of complete physical, mental and social and psychological well being.
• Health does not simply mean ‘absence of disease’ or ‘physical fitness’. 
• William Harvey (discovered blood circulation experimentally) disproved this 'good humor' hypothesis of health by demonstrating normal body temperature in persons with black bile using thermometer.
• Balanced diet, personal hygiene and regular exercise are very important to maintain good health. Yoga has been practised since time immemorial to achieve physical and mental health.
• Awareness about diseases and their effect on different bodily functions, vaccination (immunisation) against infectious diseases, proper disposal of wastes, control of vectors and maintenance of hygiene in food and water resources are necessary for achieving good health.

3.0What is the Definition of Disease?

Disease are the abnormal conditions in the body that affect its normal functioning.

Pathogens:

• Pathogens are disease causing organisms
• Most parasites are pathogens living in (or on) the host multiply and interfere with normal vital activities resulting in morphological and functional damage.
• Gut pathogens can survive harsh pH & digestive enzymes.

4.0Common Diseases in Humans

Vector: Transmits disease from one organism to another e.g. female Aedes mosquito is the vector for dengue and chikungunya, while, Anopheles spreads malaria.

5.0Measures for Preventing the Spread of infectious Diseases

• Balanced diet, yoga and regular exercise, personal hygiene, awareness about diseases and vaccination are very important to maintain good health.
• Use of vaccines and immunization programmes have enabled us to completely eradicate a deadly disease like smallpox. Large number of infectious diseases like polio, diphtheria, pneumonia and tetanus have been controlled to a large extent by the use of vaccines.
• Biotechnology is at the verge of making available newer and safer vaccines.
• Discovery of antibiotics and various drugs have enabled us to effectively treat infection
  

1. Bacterial Diseases:

Typhoid Mary (Mary Mallon), a cook by profession was a typhoid carrier who spread typhoid through the food she prepared.

2. Viral Diseases:

Common cold does not infect lungs and its symptoms usually lasts for 3-7 days

3. Helminthic Diseases:

4. Fungal Diseases:

• Heat and moisture makes the fungi thrive in skin folds such as in groin and between toes.

• Acquired from soil or belongings of infected individuals such as towels, combs, clothes etc.

5. Protozoan Diseases:

• House flies act as mechanical carrier for amoebiasis

• P. falciparum causes malignant malaria (Most serious form)

• Rupturing Of RBCs releases the toxic substance, haemozoin responsible for symptoms of disease.

AIDS/Acquired Immuno Deficiency Syndrome

• 1^st reported - 1981, Killed – Approximately 25 million people in last 25 years.

• It is deficiency of immune system, acquired during the lifetime of an individual.

• Syndrome means ‘group of symptoms’.

• Non congenital, fatal infectious disease

Sequence of events:

1. Inflected cells, (Macrophages) can survive while viruses are being replicated and released hence called HIV factory

2. HIV enters into macrophages and T-helper cells (TH) simultaneously

3. There is progressive decrease in number of helper T-cells

4. Initial symptoms: Bouts of fever, diarrhoea, weight loss

5. Later the immuno-deficient patient is prone to infections especially Mycobacterium, viruses, fungi, Toxoplasma etc.

There is always a time-lag between infection and appearance of AIDS symptoms. This may vary from a few months to many years (usually 5-10 years)

Cancer

A dreaded non-infectious disease; major cause of death all across the globe.

Carcinogens: 

Carcinogens are cancer causing agents and are of following types

1. Ionising radiations -X-rays, γ - rays
2. Non-ionising radiations-UV rays
3. Physical agents
4. Chemical agents-in tobacco smoke
5. Biological agents- Oncogenic viruses (carry viral oncogenes)
6. Diagnosis/Detection: Early detection allows the disease to be treated successfully in many cases

Tumor cells have ability to avoid detection and destruction by immune system.

↓

Approaches for treatment: 

↓

Surgery

↓

Radiotherapy: Tumor cells irradiated lethally

↓

Chemotherapy: Side effects like hair loss, anemia 

↓

Immunotherapy a-Interferons (Biological response modifiers) 

activate immune system and helps in destroying the tumor.