Meiosis has a stage called pachytene, but it is also known as pachynema because the homologous chromosomes fully synapse here, forming tetrads. It is an important stage for genetic recombination where crossing over actually occurs between maternal and paternal chromosomes. Hybrid sterility is a condition of reproductive failure, where the pachytene checkpoint acts as a surveillance mechanism which detects the aberrant products of meiosis. It plays a greater role to be one of the factors that prevent the formation of faulty gametes. The pachytene barrier has been proposed as a structure that is not only related to gene-based but also to chromosomal-based hybrid sterility because it impacts the non-haploid or aneuploid gametes.
(Session 2025 - 26)