The plasma membrane is a biological membrane that separates and protects the interior of all cells from the outside environment. It regulates the passage of materials into and out of the cell and is crucial for maintaining homeostasis..Structurally the cell` membrane of prokaryotes is similar to the eukaryotes.
The plasma membrane serves several essential functions:
The plasma membrane is composed of:
(A). Sandwich model of Plasma Membrane:- Proposed by Davson and Danielli.
The sandwich model suggests that phospholipid bilayers form structures with hydrophilic heads facing outward and hydrophobic tails inward.The hydrophilic ends of fatty acid covered by protein layer thus arrangement of protein and lipid layer remain in P-L-L-P form This model has been replaced by the fluid mosaic model.
(B). Fluid mosaic model:-
Proposed by Singer & Nicolson (1972)
The fluid mosaic model describes the plasma membrane as consisting of a phospholipid bilayer, embedded proteins,peripheral protein, cholesterol, and carbohydrates. This model emphasizes the quasifluid nature of the membrane and structure of plasma membrane.
Phospholipid is the main component of cell membrane because it
forms a continuous structural frame of the cell membrane. The phospholipid layer provides fluidity to the plasma membrane because phospholipids are rich in unsaturated fatty acid.
Cholesterol is also present in plasma membranes. Cholesterol is more rigid than phospholipid. So it helps in stability of membrane structure.
• The Quasifluid nature of lipids enable lateral movement of protein within the overall bilayer.
This ability to move within the membrane is measured as its fluidity.
Two types of protein are present in plasma membrane. (On the basis of ease of extraction)
1. Extrinsic or peripheral protein :-
These are superficially arranged on the surface of the lipid layer and can be separated easily. These proteins have enzymatic activity.
2. Intrinsic or integral protein :-
These proteins are tightly binds with phospholipid. Thus, they can not be easily removed from the membrane.
i. Partially buried – Incompletely buried through the thickness of the membrane.
ii. Totally buried – Totally buried through the complete thickness of membrane.
(Carrier Proteins and Tunnel Proteins.)
(c) Carbohydrates (sugar):-
Oligosaccharides (sugar), the glycolipids & glycoproteins on the outer surface of plasma membranes are involved in cell to cell recognition.
Best example of cell recognition is “Fertilization (where sperm & egg recognize each other)” and “Blood group Antigens”.
(Session 2025 - 26)