Which enzyme is responsible for the activation of nucleotides at the time of DNA replication?

Explanation

**Step-by-Step Text Solution:**

1. **Understanding the Question**: The question asks for the enzyme responsible for activating nucleotides during DNA replication.

2. **Identifying the Enzyme**: The enzyme that plays a crucial role in the activation of nucleotides is known as phosphorylase.

3. **Function of Phosphorylase**: Phosphorylase catalyzes the addition of phosphate groups to nucleotides, which is essential for their activation.

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