Assertion : The inhibition of activity of succinic dehydrogenase by malonate which closely resembles the substrate succinate in structure is the example of competitive inbhibition.
Reason : Competitive inhibition is the inhibition of enzyme activity when inhibitor closely resembles the substrate, in its molecular structure

A: Assertion is correct and reason is the correct explanation of assertion.
B: Assertion is correct but reason is not the correct explanation of it.
C: Assertion is true and reason is false
D: Both assertion and reason are false..

Answer

A

Explanation

The activity of an enzyme is sensitive to the presence of specific chemicals that binds to the enzyme. When the binding of the chemical shuts off enzyme activity, the process is called inhibition and the chemical is called an inhibitor. When the inhibitor closely resembles the substrate in its molecular structure and inhibits the activity of the enzyme, it is known as competitive inhibitor. Due to its close structure similarty with the substrate, the inhibitor competes with the substrate for the substrtae-binding site of the enzyme. Consequently, the substrate cannot bind and the enzyme action declines. The inhibition of succinic dehydrogenase by maltonate which closely resembles the substrate succinate in structure is the example of competitive inhibition.