Amides are least reactive of the acid derivatives towards_____reactions.

Explanation

To answer the question "Amides are least reactive of the acid derivatives towards _____ reactions," we need to analyze the reactivity of different acid derivatives.

### Step-by-Step Solution:

1. **Understanding Acid Derivatives**:
Acid derivatives include compounds like acid chlorides, anhydrides, esters, and amides. Each of these has different reactivities due to the nature of their functional groups.

2. **Reactivity Order**:
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