As per chemiosmotic coupling hypothesis, in mitochondria, protons accumulate in the

Options

A. outer membrane
B. inner membrane
C. intermembrane space
D. matrix

Answer

C

Explanation

Chemiosmotic coupling hypothesis, proposed by peter Mitchell (1961,66) (Nobel Prize in 1978) is the most widely accepted theory for oxidative phosphorylation. Reduced NAD (i.e., NADH), released from Krebs' cycle, when enters in the ETS, transport three pairs of `H^(+)` across the inner mitochondrial membrane to the intermembrane space. Similarly, NADH from glycolysis or `FADH_(2)` from Krebs' cycle transports two pairs of protons results intermembrane space. This unidirectional flow of protons results in the accumulation of protons in the intermembrane space.