The 1992 Noble Prize for medicine was awarded to Edmond H. Fischer and Edwin J. Kerbs for their work concerning .

Options

A. Reversible protein phosphorylation as a biological regulation mechanism
B. Isolation of the gene for a human disease
C. Human genome project
D. Durg designing involving inhibition of DNA synthesis of the pathogen.

Answer

**Step-by-Step Solution:**

1. **Identify the Nobel Prize Winners**: The 1992 Nobel Prize for Medicine was awarded to Edmond H. Fischer and Edwin J. Krebs.

2. **Understand the Context of Their Work**: The work for which they were awarded the Nobel Prize is related to biological processes.

3. **Review the Options Provided**:
- Option 1: Reversible protein phosphorylation as a biological regulation mechanism.
- Option 2: Isolation of gene for human disease.
- Option 3: Human genome project.
- Option 4: Drug designing involving the inhibition of DNA synthesis of pathogen.

4. **Analyze Each Option**:
- **Option 1**: This option refers to reversible protein phosphorylation, which is a key regulatory mechanism in cellular processes.
- **Option 2**: This option discusses the isolation of genes, which is significant but not directly related to the work of Fischer and Krebs.
- **Option 3**: The Human Genome Project is a large-scale project that was not the focus of their research.
- **Option 4**: Drug designing related to DNA synthesis inhibition is important but does not pertain to their specific contributions.

5. **Conclude the Correct Answer**: Based on the analysis, the correct answer is **Option 1: Reversible protein phosphorylation as a biological regulation mechanism**. This work involved understanding how reversible phosphorylation regulates various biological processes, including glucose mobilization and prevention of transplant rejection.

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