Study carefully the following stages of life cycle of malarial parasite i.e., Plasmodium. Arrange these stages in the correct sequence and select the correct answer.
1. Sporozoites leave the blood stream and enter the liver cells of man.
2. Sporozoites present in the salivary glands of female Anopheles mosquito are injected into the blood stream of man.
3. The parasite reproduces asexually in RRCs, resulting in bursting of RRCs and causing the cycles of fever, released parasites infect new RRCs.
4. The parasite reproduces asexually in liver cells, ultimately causing the rupturing of cells.
5. Two types of gametocytes i.e., microgametocytes and macrogametocytes develop in the RRCs.
6. Female Anopheles mosquito takes up the gametocytes with blood meal of an infected person.
7. Mature infective stage of the parasite i.e., sporozoites escape from intestine and migrate to the mosquito's salivary glands.
8. Fertilisation and developmental stages of the parasite take place in mosquito's stomach.

Options

A. `2 to 1 to 4 to 3 to 5 to 6 to 8 to 7`
B. `2 to 4 to 1 to 3 to 5 to 6 to 7 to 8`
C. `1 to 2 to 4 to 3 to 5 to 6 to 8 to 7 `
D. `6 to 8 to 7 to 4 to 5 to 2 to 3 to 1`

Answer

To arrange the stages of the life cycle of the malarial parasite, Plasmodium, in the correct sequence, we need to analyze each step carefully. Here’s the step-by-step solution:

1. **Step 2**: Sporozoites present in the salivary glands of female Anopheles mosquito are injected into the bloodstream of man.
- This is the initial step where the parasite enters the human host through the bite of the mosquito.

2. **Step 1**: Sporozoites leave the bloodstream and enter the liver cells of man.
- After entering the bloodstream, the sporozoites migrate to the liver cells where they will undergo further development.

3. **Step 4**: The parasite reproduces asexually in liver cells, ultimately causing the rupturing of cells.
- In the liver, the sporozoites undergo asexual reproduction, leading to the destruction of liver cells.

4. **Step 3**: The parasite reproduces asexually in red blood cells (RBCs), resulting in the bursting of RBCs and causing cycles of fever; released parasites infect new RBCs.
- After the liver stage, the parasites enter the bloodstream and infect RBCs, leading to further asexual reproduction and causing symptoms of malaria.

5. **Step 5**: Two types of gametocytes, i.e., microgametocytes and macrogametocytes, develop in the RBCs.
- As the parasites continue to reproduce, some of them develop into gametocytes, which are necessary for the next stage of the life cycle.

6. **Step 6**: Female Anopheles mosquito takes up the gametocytes with the blood meal of an infected person.
- When the mosquito bites an infected person, it ingests the gametocytes along with the blood.

7. **Step 8**: Fertilization and developmental stages of the parasite take place in the mosquito's stomach.
- Inside the mosquito, the gametocytes undergo fertilization and develop into zygotes.

8. **Step 7**: Mature infective stage of the parasite, i.e., sporozoites, escape from the intestine and migrate to the mosquito's salivary glands.
- Finally, the sporozoites develop and migrate to the salivary glands of the mosquito, ready to be transmitted to another human host.

### Final Sequence:
- 2 → 1 → 4 → 3 → 5 → 6 → 8 → 7

### Correct Answer: Option A