Which of the following are the reason (s) for Rheumatoid arthritis ? Choose the correct option.
(i) The ability to differentiate pathogens or foreign molecules from self cells increases.
(ii) Body attacks self cells.
(iii) More antibodies are produced in the body.
(iv) The ability to differentiate pathogens or foreign molecules from self cells is lost.

Options

A. (i) and (ii)
B. (ii) and (iv)
C. (iii) and (iv)
D. (i) and (iii)

Answer

B

Explanation

The body is normally able to distinguish its own self-antigens from foreign nonself antigens and does not attack (immunologic) against itself. At times, the body loses tolerance and mounts an abnormal immune attack. Autoimmue disease results from the activation of self-reactive T and B cells. Rheumatoid arthritis is an example of autoimmune disease.