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Amides undergo hydrolysis to yield carbo...

Amides undergo hydrolysis to yield carboxylic acid plus amine on heating in either aqueous acid or aqueous base. The conditions required for amide hydrolysis are more severe than those required for the hydrolysis of esters, anhydrides or acid chlorides, but the mechanism is similar (nucleophilic acyl substitution). Nucleophilic acyl substitutions involve a tetrahedral intermediate, hence these are quite different from alkyl substitution
`(RCH_(2)Broverset(NaCN)to RCH_(2)CN)`
which involves a pentavalent intermediate or transition state. One of the important reactions of esters is their reaction with two equivalent of Grignard reagent to give tertiary alcohols.
The mechanism involved during the hydrolysis of acid derivatives is:

A

elimination addition

B

addition -elimination

C

nucleophilic addition elimination

D

Electrophilic addition elimination

Text Solution

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The correct Answer is:
c

Nucleophilic addition elimination
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Amides undergo hydrolysis to yield carboxylic acid plus amine on heating in either aqueous acid or aqueous base. The conditions required for amide hydrolysis are more severe than those required for the hydrolysis of esters, anhydrides or acid chlorides, but the mechanism is similar (nucleophilic acyl substitution). Nucleophilic acyl substitutions involve a tetrahedral intermediate, hence these are quite different from alkyl substitution (RCH_(2)Broverset(NaCN)to RCH_(2)CN) which involves a pentavalent intermediate or transition state. One of the important reactions of esters is their reaction with two equivalent of Grignard reagent to give tertiary alcohols. For which functional derivative of carboxylic acids, acidic hydrolysis is the fastest?

Amides undergo hydrolysis to yield carboxylic acid plus amine on heating in either aqueous acid or aqueous base. The conditions required for amide hydrolysis are more severe than those required for the hydrolysis of esters, anhydrides or acid chlorides, but the mechanism is similar (nucleophilic acyl substitution). Nucleophilic acyl substitutions involve a tetrahedral intermediate, hence these are quite different from alkyl substitution (RCH_(2)Broverset(NaCN)to RCH_(2)CN) which involves a pentavalent intermediate or transition state. One of the important reactions of esters is their reaction with two equivalent of Grignard reagent to give tertiary alcohols. Which of the following constitutes the best substrate during the acidic hydrolysis of amides?

Amides undergo hydrolysis to yield carboxylic acid plus amine on heating in either aqueous acid or aqueous base. The conditions required for amide hydrolysis are more severe than those required for the hydrolysis of esters, anhydrides or acid chlorides, but the mechanism is similar (nucleophilic acyl substitution). Nucleophilic acyl substitutions involve a tetrahedral intermediate, hence these are quite different from alkyl substitution (RCH_(2)Broverset(NaCN)to RCH_(2)CN) which involves a pentavalent intermediate or transition state. One of the important reactions of esters is their reaction with two equivalent of Grignard reagent to give tertiary alcohols. When is treated with two equivalent of methyl magnesium iodide and the product acidified the final product will be

Nucleophilic bimolecular substitution involve:

Rate of hydrolysis : ester, acid chloride, acid anhydride

Acyl nucleophilic substitution (SNAC) (SNAE)

Acid halides are more reactive than acid amides towards the hydrolysis.

Hydrolysis of nucleic acid yields

NARAYNA-CARBOXYLIC ACID-All Questions
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  2. The probable product(s) of the following reaction is/are

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  4. Amides undergo hydrolysis to yield carboxylic acid plus amine on heati...

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  5. Amides undergo hydrolysis to yield carboxylic acid plus amine on heati...

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  9. An organic lactum (A) on acid hydrolysis produces an amino acid (B) wh...

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  10. Which reagent (X) is used to convert to I to II?

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  11. Which is true for the above reaction?

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