If the some reason the parietal cells of the gut epithelium become partially non-functional, what is likely to happen

Options

A. The pancreatic enzymes and specially the trypsin and liase will not work efficiently
B. The Ph of stomach will fall abrupthly
C. Steapsin will be more effective
D. Protein will not be adequately hydrolysed by pepsin into proteoses and peptones

Explanation

### Step-by-Step Solution:

1. **Understanding the Role of Parietal Cells**:
- Parietal cells are specialized cells located in the lining of the stomach. Their primary function is to secrete hydrochloric acid (HCl), which creates an acidic environment in the stomach. This acidity is crucial for the activation of digestive enzymes and for the digestion of food.

2. **Consequences of Non-Functional Parietal Cells**:
- If the parietal cells become partially non-functional, the secretion of hydrochloric acid will be impaired. This will lead to a less acidic environment in the stomach.

3. **Impact on Digestion**:
- The acidic environment is essential for the activation of pepsinogen to pepsin, an enzyme that is responsible for the hydrolysis of proteins into smaller peptides. Without sufficient acidity, pepsinogen may not be activated effectively, leading to inadequate protein digestion.

4. **Analyzing the Options**:
- **Option 1**: "Pancreatic enzymes, especially trypsin and lipase will not work efficiently." - This is incorrect because pancreatic enzymes are activated in the small intestine and are not directly affected by stomach acidity.
- **Option 2**: "The pH of the stomach will fall abruptly." - This is incorrect because the pH will likely rise (become less acidic) due to reduced acid secretion.
- **Option 3**: "Trypsin will be more effective." - This is incorrect as trypsin is activated in the small intestine and is not dependent on stomach acidity.
- **Option 4**: "Protein will not be adequately hydrolyzed by pepsin into proteoses and peptones." - This is correct because the lack of adequate hydrochloric acid will hinder the activation of pepsin, leading to insufficient protein digestion.

5. **Conclusion**:
- The most likely outcome of parietal cells becoming partially non-functional is that protein digestion will be significantly impaired due to the inadequate hydrolysis of proteins by pepsin.

### Final Answer:
The correct answer is that protein will not be adequately hydrolyzed by pepsin into proteoses and peptones.

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