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The disease sickle-cell anaemia is caus...

The disease sickle-cell anaemia is caused by the substitution of `overset("(i)") "____"` by `overset("(ii)") "____"` at the `overset("(iii)") "____"` position of `overset("(iv)") "____"` globin chain of haemoglobin molecule
Which of the following correctly fills the blanks in the above statements ?

A

Valine by glutamic acid at sixth position of alpha chain of haemoglobin

B

Valine by glutamic acid at sixth position of beta chain of haemoglobin

C

Gluacid by valine at sixth position of alpha chain of haemoglobin

D

Glutomic acid by valine at sixth position of beta chain of haemoglobin

Text Solution

Verified by Experts

The correct Answer is:
D
The sixth amino acid in `Beta`-chain of normal haemoglobin is gluatamic acid. In sickle cell haemoglobin this amion acid is replaced by valine.
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