Choose the wrong statement :

Options

A. VNTR belong to a class of mini-satellite DNA
B. Satellite DNA normally do not code for proteins
C. DNA sequencing work on the principle developed by Frederick Sanger
D. DNA fingerprinting involves identifying similarities in repetitive DNA

Answer

To solve the question of identifying the wrong statement among the provided options, we will analyze each statement one by one.

### Step-by-Step Solution:

1. **Statement A: VNTR belongs to a class of mini-satellite DNA.**
- VNTR stands for Variable Number Tandem Repeats, and it is indeed classified as a type of mini-satellite DNA.
- **Conclusion:** This statement is true.

2. **Statement B: Satellite DNAs normally do not code for proteins.**
- Satellite DNAs are repetitive sequences of DNA that do not code for proteins. This is a well-established fact in molecular biology.
- **Conclusion:** This statement is true.

3. **Statement C: DNA sequencing works on the principle developed by Frederick Sanger.**
- Frederick Sanger developed the chain-termination method for DNA sequencing, which is widely used in sequencing DNA.
- **Conclusion:** This statement is true.

4. **Statement D: The Human Genome Project was coordinated by the US Department of Energy and the National Institute of Health.**
- The Human Genome Project (HGP) was indeed a collaborative project coordinated by these two organizations, among others.
- **Conclusion:** This statement is true.

5. **Statement E: DNA fingerprinting involves identifying similarities in repetitive DNA.**
- DNA fingerprinting is a technique used to identify individuals based on their unique DNA characteristics, which are not necessarily based on similarities in repetitive DNA. Instead, it focuses on the unique patterns of DNA.
- **Conclusion:** This statement is false.

### Final Answer:
The wrong statement is **E: DNA fingerprinting involves identifying similarities in repetitive DNA.**