In mitosis, splitting of chromatids upto the centromere takes place in :–

Options

A. Prophase
B. Metaphase
C. Anaphase
D. Telephase

Answer

**Step-by-Step Solution:**

1. **Understanding Mitosis Phases**: Mitosis consists of several phases: Prophase, Metaphase, Anaphase, and Telophase. Each phase has specific events that occur.

2. **Analyzing Prophase**: In Prophase, the chromosomes condense, the nuclear envelope breaks down, and the nucleolus disappears. However, no splitting of chromatids occurs in this phase.

3. **Analyzing Metaphase**: During Metaphase, chromosomes align at the cell's equatorial plane (metaphase plate). The chromatids are still attached at the centromere, so no splitting occurs here either.

4. **Analyzing Anaphase**: Anaphase is the phase where the centromeres split, and the sister chromatids are pulled apart towards opposite poles of the cell. This is the phase where the splitting of chromatids occurs up to the centromere.

5. **Analyzing Telophase**: In Telophase, the separated chromatids reach the poles, and the nuclear envelope begins to reform around each set of chromosomes. There is no splitting of chromatids in this phase.

6. **Conclusion**: The correct answer to the question "In mitosis, splitting of chromatids up to the centromere takes place in" is **Anaphase**.

**Final Answer**: Anaphase.

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