In which stage the Chromosomes combine and begin to separate from each other during meiosis cell division :-

Options

A. Pachytene
B. Diplotene
C. Zygotene
D. Diakinesis

Answer

To answer the question about the stage in which chromosomes combine and begin to separate from each other during meiosis, we can break down the process step by step:

### Step-by-Step Solution:

1. **Understanding Meiosis**: Meiosis is a type of cell division that reduces the chromosome number by half and leads to the formation of gametes (sperm and eggs). It consists of two successive divisions: meiosis I and meiosis II.

2. **Identifying Key Stages**: The stages of meiosis include:
- Prophase I (which has several sub-stages: leptotene, zygotene, pachytene, diplotene, and diakinesis)
- Metaphase I
- Anaphase I
- Telophase I
- Meiosis II (which also has similar stages)

3. **Focusing on Prophase I**: During Prophase I, homologous chromosomes pair up in a process called synapsis. This stage is crucial for genetic recombination.

4. **Analyzing the Stages**:
- **Zygotene**: This is when synapsis begins, and homologous chromosomes start to pair.
- **Pachytene**: This is when the homologous chromosomes are fully paired, and crossing over occurs, leading to genetic recombination.
- **Diplotene**: In this stage, the homologous chromosomes begin to separate but remain connected at points called chiasmata.
- **Diakinesis**: This is the final stage of prophase I, where the nuclear envelope breaks down and the chromosomes condense further.

5. **Conclusion**: The stage where chromosomes combine and begin to separate from each other is the **Diplotene** stage. In this stage, the homologous chromosomes are still connected at the chiasmata but are starting to separate.

### Final Answer:
The correct answer is **Diplotene**.

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