Lysosomes are not helpful in :-

Options

A. Osteogenesis
B. Cellular digestion
C. Metamorphosis in frog
D. Lipogenesis

Answer

### Step-by-Step Solution:

1. **Understanding Lysosomes**:
- Lysosomes are membrane-bound organelles filled with hydrolytic enzymes that help in the digestion of various biomolecules. They are often referred to as "suicidal bags" because they can break down cellular components.

2. **Analyzing the Options**:
- The question asks which process lysosomes are not helpful in. We need to evaluate each option provided.

3. **Option 1: Osteogenesis**:
- Osteogenesis refers to the formation of bone. Lysosomes are involved in the breakdown of cartilage by chondroclasts, which helps in the process of osteogenesis. Therefore, lysosomes are helpful in this process.

4. **Option 2: Cellulatization**:
- Cellulatization is the process of cellular digestion. Since lysosomes contain hydrolytic enzymes, they play a crucial role in the digestion of cellular materials. Thus, lysosomes are helpful in this process as well.

5. **Option 3: Metamorphosis in Frogs**:
- During the metamorphosis of frogs, lysosomes help in the breakdown of larval organs. They are involved in the removal of these structures, indicating that lysosomes are also helpful in this process.

6. **Option 4: Lipogenesis**:
- Lipogenesis is the synthesis of lipids, which occurs primarily in the smooth endoplasmic reticulum. Lysosomes do not play a role in this process, making this the correct answer to the question.

### Conclusion:
- The correct answer is **Option 4: Lipogenesis**, as lysosomes are not involved in lipid synthesis.