The chromosomes appear as beaded structures at :-

Options

A. Leptotene
B. Pachytene
C. Diakinesis
D. Telophase–I

Answer

To answer the question "The chromosomes appear as beaded structures at:", we need to analyze the different stages of meiosis where chromosomes undergo various forms of condensation and organization.

### Step-by-Step Solution:

1. **Understand the Question**: The question asks at which stage chromosomes appear as beaded structures. This typically refers to the way chromosomes are visualized under a microscope during certain phases of cell division.

2. **Identify the Stages**: The relevant stages of meiosis to consider are:
- Leptotene
- Pachytene
- Diplotene
- Telophase I

3. **Analyze Each Stage**:
- **Leptotene**: This is the first stage of prophase I in meiosis. During this stage, chromosomes begin to condense and become visible as thin threads. They appear as beaded structures due to the presence of chromatin that is starting to condense.
- **Pachytene**: This is the next stage where chromosomes are fully condensed and homologous chromosomes are paired. While they are more condensed, they do not typically appear as beaded structures.
- **Diplotene**: In this stage, the chromosomes are further condensed and the homologous chromosomes start to separate, so they do not appear as beaded structures.
- **Telophase I**: In this stage, the nuclear membrane reappears and the chromosomes are already fully condensed, again not appearing as beaded structures.

4. **Conclusion**: Based on the analysis, the correct answer is **Leptotene**, where chromosomes first appear as beaded structures due to the initial condensation of chromatin.

### Final Answer:
The chromosomes appear as beaded structures at **Leptotene**.

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