Nucleosome is made up of :–

Options

A. Nonhistone protein + RNA
B. Histone protein and DNA
C. Non–histone and histone protein
D. Phospholipid and protein

Answer

To answer the question "Nucleosome is made up of:", we can break down the explanation into several steps:

### Step-by-Step Solution:

1. **Understanding Nucleosome Structure**:
- A nucleosome is a fundamental unit of DNA packaging in eukaryotic cells. It consists of a core of histone proteins around which DNA is wrapped.

2. **Identifying the Components**:
- The nucleosome is primarily made up of:
- **Histone Proteins**: There are four main types of histone proteins that form the core of the nucleosome: H2A, H2B, H3, and H4. These proteins are positively charged.
- **DNA Segment**: The DNA wraps around the histone octamer, forming a structure that helps in compacting the DNA within the nucleus.

3. **Analyzing the Options**:
- Given the options:
1. Non-histone proteins plus RNA
2. Histone proteins and DNA
3. Non-histone and histone proteins
4. Phospholipid and protein
- We can eliminate the options that do not contain both histone proteins and DNA, as these are the key components of a nucleosome.

4. **Selecting the Correct Answer**:
- The only option that accurately describes the composition of a nucleosome is:
- **Option 2: Histone proteins and DNA**.

### Conclusion:
Thus, the correct answer to the question "Nucleosome is made up of:" is **Histone proteins and DNA**.

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