A hormone which do not bind with membrane bounded receptor is :

Options

A. Insulin
B. Thyrocalcitonin
C. Oxytocin
D. Progestrone

Answer

To determine which hormone does not bind with membrane-bound receptors, we can follow these steps:

### Step 1: Understand the Types of Hormones
Hormones can be classified into two main types based on their structure and how they interact with cells:
- **Peptide/Protein Hormones**: These hormones are generally larger molecules and include insulin, thyrocalcitonin, and oxytocin. They typically bind to receptors located on the cell membrane.
- **Steroid Hormones**: These hormones are derived from cholesterol and include hormones like progesterone, cortisol, and estrogen. They generally pass through the cell membrane and bind to intracellular receptors.

### Step 2: Analyze the Given Options
The options provided are:
1. Insulin
2. Thyrocalcitonin
3. Oxytocin
4. Progesterone

### Step 3: Identify the Binding Characteristics
- **Insulin**: A peptide hormone that binds to membrane-bound receptors.
- **Thyrocalcitonin**: A peptide hormone that also binds to membrane-bound receptors.
- **Oxytocin**: Another peptide hormone that binds to membrane-bound receptors.
- **Progesterone**: A steroid hormone that binds to intracellular receptors.

### Step 4: Conclusion
Based on the analysis, the hormone that does not bind with membrane-bound receptors is **Progesterone**, as it binds to intracellular receptors instead.

### Final Answer
The hormone which does not bind with membrane-bound receptor is **Progesterone**.

---