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A couple both carriers of sickle cell an...

A couple both carriers of sickle cell anaemia planning to get married, wants to know the chances of having anaemic progeny

A

1

B

0.75

C

0.25

D

0.5

Text Solution

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The correct Answer is:
C
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Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If one parent has sickle cell anemia and the other has sickle cell trait, there is __________that their children will have sickle cell anemia and ___________will have sickle cell trait.

Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If both parents have sickle cell trait, then there is _______________of the child having sickle cell trait.

Write the genotype of (i) an individual who is carrier of sickle cell anaemia gene but apparently unaffected, and (ii) an individual affected with the disease.

Read the following five statement five statement (A to E )and select the option with all correct statement : (A) Down's syndrome id due to trisomy of chromosome 22 , (b) Genes are the due of inhetitance ( c) Variation is the degree by which progeny differ from their parents. (d) In chicken ,sex chromosome in male are ZW ,and in females are ZZ (E) Sickle cell anaemia is caused due to change of one base in the gene coding for b-chain of haemoglobin