Shape of chromosome can be best observed during

Options

A. Prophase
B. Metaphase
C. Anaphase
D. Telophase

Explanation

To determine when the shape of chromosomes can be best observed, we need to analyze the different stages of cell division, specifically during mitosis. Here’s a step-by-step solution:

### Step-by-Step Solution:

1. **Understanding Chromosome Structure**:
- Chromosomes are structures that carry genetic information and are made up of chromatin. They condense and become visible during cell division.

2. **Identifying Mitosis Stages**:
- Mitosis consists of several stages: prophase, metaphase, anaphase, and telophase. Each stage has distinct characteristics regarding chromosome visibility.

3. **Prophase**:
- During prophase, chromatin condenses into visible chromosomes. However, they are not yet fully organized, and their shape is not clearly defined.

4. **Metaphase**:
- In metaphase, chromosomes align at the cell's equatorial plane. This is the stage where chromosomes are most condensed and their morphology (shape) can be best observed. They appear as distinct X-shaped structures, making it easy to study their number and shape.

5. **Anaphase**:
- In anaphase, chromosomes are pulled apart to opposite poles of the cell. While the genetic material is being separated, the focus is more on the movement rather than the shape of the chromosomes.

6. **Telophase**:
- During telophase, the chromosomes begin to de-condense back into chromatin as the cell prepares to divide into two daughter cells. The shape of the chromosomes is not easily observed in this stage.

7. **Conclusion**:
- Based on the analysis, the best stage to observe the shape of chromosomes is during **metaphase**.

### Final Answer:
The shape of chromosomes can be best observed during **metaphase**.