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Which statement is false about yeast art...

Which statement is false about yeast artificial chromo- somes (YACs)?

A

They are used to clone DNA fragments of more than 1 Mb in size

B

They have been exploited extensively in mapping the large genomes like in human genome project

C

They contain telomeric sequence, the centromere and autonomously replicating sequence from yeast chromosomes

D

They have cos sites

Text Solution

AI Generated Solution

The correct Answer is:
To determine which statement is false about yeast artificial chromosomes (YACs), we will analyze each statement provided in the question. ### Step-by-Step Solution: 1. **Understand YACs**: Yeast Artificial Chromosomes (YACs) are genetically engineered chromosomes derived from the yeast species Saccharomyces cerevisiae. They are used to clone large fragments of DNA. 2. **Check the Size of DNA Fragments**: YACs can clone DNA fragments ranging from 100 kilobases (KB) to about 1 megabase (MB). Therefore, any statement claiming they can clone DNA fragments larger than 1MB is incorrect. 3. **Evaluate the Statements**: - **Statement 1**: "They are used to clone DNA fragments of more than 1MB in size." - This statement is **false** because YACs can clone fragments up to 1MB but not more than that. - **Statement 2**: "They have been exploited extensively in mapping the large genomes like the Human Genome Project." - This statement is **true**. YACs were indeed used in the Human Genome Project for mapping large genomes. - **Statement 3**: "They have telomeric sequences, centromeres, and ARS (Autonomously Replicating Sequences) from the yeast chromosome." - This statement is **true**. YACs include these components derived from yeast. - **Statement 4**: "They have caussate." - This statement is **false**. YACs do not have caussate; they consist of telomeres, centromeres, and ARS. 4. **Conclusion**: Based on the analysis, the false statement about YACs is the one that claims they can clone DNA fragments of more than 1MB in size. ### Final Answer: The false statement about yeast artificial chromosomes (YACs) is: "They are used to clone DNA fragments of more than 1MB in size."
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