Mark an incorrect statement regarding land mark event in biotechnology:

Options

A. An American company got patent right on Basmati rice through US Patent and Trademark Office in 1997
B. Introduction of human `alpha`- lactalbumin gene was done in cow Rosis in 1997
C. Eli Lilly produced in 1983
D. The first clinical gene was given in 1997 to a four-year-old girl with adenosine deaminase deficency

Answer

To determine the incorrect statement regarding landmark events in biotechnology, we will analyze each option provided in the question.

### Step-by-Step Solution:

1. **Analyze Option A**:
- The statement mentions that Eli Lilly, an American company, prepared Humulin in 1983.
- Humulin is indeed a form of human insulin produced through genetic engineering by Eli Lilly.
- However, while this was a significant achievement, it is often debated whether it was as groundbreaking as other events in biotechnology. Therefore, this option may be considered less impactful compared to others.

2. **Analyze Option B**:
- This option states that clinical gene therapy was first administered in 1990 to a four-year-old child with ADA (Adenosine Deaminase) deficiency.
- This event is recognized as a landmark in biotechnology, as it was one of the first successful gene therapy trials, making it a significant milestone.

3. **Analyze Option C**:
- Here, the introduction of the Human Alpha Lactalbumin gene into a cow named Rosie in 1997 is mentioned.
- This event is also considered a landmark because it demonstrated the potential of genetic engineering in agriculture and the production of human proteins in livestock.

4. **Analyze Option D**:
- This option refers to an American company obtaining patent rights for "Golden Rice" through the US Patent and Trademark Office.
- The development of Golden Rice, which is genetically modified to produce vitamin A, is indeed a landmark event in biotechnology, particularly in addressing nutritional deficiencies.

### Conclusion:
After analyzing all options, **Option A** is marked as the incorrect statement regarding landmark events in biotechnology. While Humulin was a significant achievement, it is often overshadowed by other more impactful events listed in the other options.

### Final Answer:
**Option A** is the incorrect statement regarding landmark events in biotechnology.

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