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The ADA gene is crusial for:...

The ADA gene is crusial for:

A

erythropoiesis

B

functioning of immune system

C

enmbryoinic development

D

early dectection of SCID

Text Solution

AI Generated Solution

The correct Answer is:
To answer the question "The ADA gene is crucial for:", we need to analyze the role of the ADA gene and its implications in various biological processes. Here’s a step-by-step breakdown of the solution: ### Step-by-Step Solution: 1. **Identify the ADA Gene**: - The ADA gene stands for adenosine deaminase. It encodes an enzyme that is vital for purine metabolism. 2. **Understand the Function of Adenosine Deaminase**: - Adenosine deaminase is an essential enzyme that helps in the breakdown of adenosine, which is important for the proper functioning of the immune system. 3. **Location of ADA Gene Expression**: - The ADA gene is predominantly expressed in immune cells, particularly in T and B lymphocytes, which are critical components of the immune response. 4. **Evaluate the Options**: - **Erythropoiesis**: This is the process of red blood cell (RBC) development. The ADA gene does not play a crucial role here, so this option is incorrect. - **Functioning of Immune System**: While the ADA gene is important for immune function, the question asks for a specific crucial role, which leads us to consider other options. - **Embryonic Development**: The ADA gene is crucial for embryonic development because it provides the necessary immunity during fetal development. Without it, the fetus would not be able to develop a proper immune system, leading to severe complications or death. - **Early Detection of SCID**: SCID (Severe Combined Immunodeficiency) is a condition resulting from ADA deficiency, but the question asks for the role of the ADA gene itself, not its detection. 5. **Conclusion**: - Given the analysis, the correct answer is that the ADA gene is crucial for **embryonic development**. Without the ADA gene, the fetus would lack the necessary immune function, which could lead to its demise. ### Final Answer: The ADA gene is crucial for **embryonic development**. ---
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Read the following five statement (A to E) about gene therapy and select the option with all correct statement: (A) The first clinical gene therapy was given in 1990 to a patient fo emphysema. (B) Gene therapy is a collection of methods that allows correction of a gene defect. (C) Adenosine deaminase (ADA) enzyme is crucial for the immune system to function. (D) Adenosine deaminase (ADA) deficiency is caused due to the duplication of the gene for adenosine deaminase. (E) ADA deficiency can be cured by bone marrow transplantation.

ADA enzyme is crucial for ................ system to function.

The enzyme ADA, that is crucial for the immune system to function is abbreviated as :

Assertion: In gene therapy of SCID, a patient requires periodic infusion of genetically engineered lymphocytes Reason :If the ADA gene is introducted into cells at early embryonic stage, it could be a permanent cure

Gene therapy aims in correcting diseases caused by defective genes. A child is suffering from a disease due to deficiency of ADA enzyme. ADA gene which normally produces the enzyme is missing in the patient. Recommend any two methods to treat the child.

During gene therapy , gene is inserted for .

Assertion : The first clinical gene for ADA therapy was given to cure SCID Reason : The normal gene was delivered into the patient's cell using retroviral vector

In some children ADA deficiency is cured by ___________transplant

Other than gene therapy , which of the following temporary remedies have been previously used for treating ADA deficiency ?

Injecting functional adenosine deaminase into a patients (lacking ADA gene) blood cells may be considered as