Which of the following are the reasons for rheumatoid Arthritis?
(i) Lymphocytes becomes more active(ii) Body attacks self cells.
(iii) More antibodies are produced in the body
(iv) The ability to differentiate pathogens or foreign molecule from self cells is lost

Options

A. ii, iii and iv
B. ii and iv
C. ii, iii and iv
D. I and iv

Answer

To determine the reasons for rheumatoid arthritis, we need to analyze each of the given statements one by one.

### Step-by-Step Solution:

1. **Understanding Rheumatoid Arthritis**:
- Rheumatoid arthritis is an autoimmune disorder characterized by inflammation of the joints, particularly affecting the synovial membrane. This inflammation leads to painful swelling and can result in joint damage.

2. **Analyzing Statement (i)**:
- "Lymphocytes become more active."
- In rheumatoid arthritis, the immune system does not simply increase lymphocyte activity; rather, it misdirects the immune response against the body's own tissues. Therefore, this statement is **false**.

3. **Analyzing Statement (ii)**:
- "Body attacks self cells."
- This statement is true because in rheumatoid arthritis, the immune system mistakenly attacks the synovial membrane, which is a part of the body. Thus, this statement is **true**.

4. **Analyzing Statement (iii)**:
- "More antibodies are produced in the body."
- While antibodies are involved in the immune response, rheumatoid arthritis does not necessarily mean an overall increase in antibody production. Instead, the body produces antibodies against its own tissues. Therefore, this statement is **false**.

5. **Analyzing Statement (iv)**:
- "The ability to differentiate pathogens or foreign molecules from self cells is lost."
- This statement is true and is a key characteristic of autoimmune diseases, including rheumatoid arthritis. The immune system fails to distinguish between self and non-self, leading to the attack on the body's own cells. Thus, this statement is **true**.

### Conclusion:
The true statements regarding the reasons for rheumatoid arthritis are:
- (ii) Body attacks self cells.
- (iv) The ability to differentiate pathogens or foreign molecules from self cells is lost.

Therefore, the most appropriate answer is **option B** (ii and iv).