Refer to the given statements regarding malarial parasite and select the incorrect ones.
I. Infective stage of Plasmodium in man is sporozite which reached the liver through blood.
II. In the liver of man parasite reproduces sexually producing a large number of metacryptomerozoids in blood.
III. When female Anopheles sucks blood the gametocytes are taken in and they become lodged in the salivary glands as ookinete.
IV. The sexual stage, gametocytes of Plasmodium developes in RBCs of man.

Options

A. I and II
B. II and III
C. I and IV
D. II and IV

Answer

To solve the question regarding the incorrect statements about the malarial parasite, we will analyze each statement one by one.

### Step-by-step Solution:

1. **Statement I**: "Infective stage of Plasmodium in man is sporozoite which reached the liver through blood."
- **Analysis**: This statement is correct. The sporozoites are the infective form of Plasmodium that enter the human bloodstream through the bite of an infected female Anopheles mosquito and subsequently travel to the liver.

2. **Statement II**: "In the liver of man parasite reproduces sexually producing a large number of metacryptomerozoids in blood."
- **Analysis**: This statement is incorrect. The reproduction that occurs in the liver is asexual, leading to the formation of merozoites, not metacryptomerozoids. Merozoites are released into the bloodstream from the liver, where they can invade red blood cells.

3. **Statement III**: "When female Anopheles sucks blood the gametocytes are taken in and they become lodged in the salivary glands as ookinete."
- **Analysis**: This statement is incorrect. When the female Anopheles mosquito takes a blood meal, it ingests gametocytes, which then undergo fertilization in the mosquito's gut to form ookinetes. Ookinetes do not lodge in the salivary glands; instead, they develop into sporozoites that migrate to the salivary glands.

4. **Statement IV**: "The sexual stage, gametocytes of Plasmodium develops in RBCs of man."
- **Analysis**: This statement is correct. The gametocytes of Plasmodium do develop in the red blood cells of humans, which are then taken up by the mosquito during a blood meal.

### Conclusion:
The incorrect statements are **Statement II** and **Statement III**.