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Is it true that if the dissolved oxygen ...

Is it true that if the dissolved oxygen level drops to zero, the water will become septic. Given an example which could lower the dissolved oxygen content of an aquatic body.

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Yes , it is true in case of zero level of dissolved oxygen (DO), the water becomes septic. Organic pollution like fertillser in aquatic bodies is responsibel for lowering (upto zero) the level of dissolved oxygen.
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