In Phenylketonuria accumulation a phenylanine generally occurs in

Options

A. brain
B. kidney
C. liver
D. skin

Answer

### Step-by-Step Solution:

1. **Understanding Phenylketonuria (PKU)**:
- Phenylketonuria is a genetic disorder caused by the deficiency of the enzyme phenylalanine hydroxylase. This enzyme is responsible for converting the amino acid phenylalanine into another amino acid, tyrosine.

2. **Identifying the Accumulation**:
- In individuals with PKU, due to the absence of this enzyme, phenylalanine accumulates in the body. This accumulation primarily occurs in various organs, but it is particularly harmful to the brain.

3. **Effects of Accumulation**:
- The high levels of phenylalanine can lead to severe neurological issues, including mental retardation, if not managed properly. The brain is the most affected organ due to its sensitivity to elevated phenylalanine levels.

4. **Other Organs Involved**:
- While phenylalanine can accumulate in other organs like the liver, kidneys, and skin, the most critical and damaging accumulation occurs in the brain.

5. **Conclusion**:
- Therefore, in Phenylketonuria, the accumulation of phenylalanine generally occurs in the brain.

### Final Answer:
In Phenylketonuria, the accumulation of phenylalanine generally occurs in the **brain**.

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