Which of the following WBC has the largest nucleus?

Options

A. Lymphocyte
B. Monocyte
C. Eosinophic
D. Basophic

Answer

To determine which white blood cell (WBC) has the largest nucleus, we can analyze the characteristics of the WBC types mentioned: lymphocytes, monocytes, and basophils.

### Step-by-Step Solution:

1. **Identify the Types of WBCs**: The question provides three types of WBCs to consider: lymphocytes, monocytes, and basophils.

2. **Examine Lymphocytes**:
- Lymphocytes can vary in size (large or small).
- They are spherical in shape.
- Their nucleus is relatively large but not the largest among WBCs, as it surrounds the cytoplasm closely.

3. **Examine Monocytes**:
- Monocytes are known to be large cells.
- They have a very large, kidney-shaped nucleus that occupies a significant portion of the cell.
- This suggests that monocytes have one of the largest nuclei among WBCs.

4. **Examine Basophils**:
- Basophils have large cytoplasmic granules that can obscure the view of the nucleus.
- When stained, the nucleus is visible but typically has a lobed structure (usually two lobes).
- The presence of lobes indicates that the nucleus is not as large as that of monocytes.

5. **Conclusion**: Based on the analysis, the WBC with the largest nucleus is the **monocyte**.

### Final Answer:
The WBC with the largest nucleus is the **monocyte**.

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