Drug that increases cardiovascular effects is

Options

A. Nicotine+Cocaine
B. Benzodiazepine+Barbiturate
C. Barbiturates + Novacaine
D. Insulin + amphetamine

Answer

**Step-by-Step Solution:**

1. **Understanding the Question**: The question asks for drugs that increase cardiovascular effects. This means we are looking for substances that enhance heart rate, blood pressure, or overall cardiovascular activity.

2. **Analyzing the Options**: We need to evaluate the given options to identify which one includes drugs known to increase cardiovascular effects.

3. **Option 1 - Nicotine and Cocaine**:
- Both nicotine and cocaine are stimulants.
- Nicotine is known to increase heart rate and blood pressure by stimulating the release of adrenaline.
- Cocaine also has stimulant effects, leading to increased heart rate and potential vasoconstriction, which raises blood pressure.
- Therefore, this combination is likely to increase cardiovascular effects.

4. **Option 2 - Benzodiazepine and Barbiturates**:
- Benzodiazepines and barbiturates are central nervous system depressants.
- They primarily increase sedation and do not enhance cardiovascular activity.
- Hence, this option is incorrect.

5. **Option 3 - Barbiturates and Novocaine**:
- Barbiturates are depressants, and novocaine (a local anesthetic) also has a depressant effect.
- This combination would not increase cardiovascular effects but rather decrease them.
- Therefore, this option is incorrect.

6. **Option 4 - Insulin and Amphetamine**:
- Insulin is a hormone that lowers blood sugar levels, while amphetamine is a stimulant.
- The combination of these two does not directly relate to cardiovascular effects, as insulin's primary role is metabolic, and amphetamines can actually counteract some effects of insulin.
- Thus, this option is also incorrect.

7. **Conclusion**: After evaluating all options, the correct answer is **Option 1: Nicotine and Cocaine**, as these drugs are known to increase cardiovascular effects.