Which of the following statements is not correct regarding ACTH?

Options

A. It is secreated by the anterior lobe of pituitary.
B. It regulates skin pigmentation in human beings.
C. It acts on the adrenal cortex and it mainly stimulates the secreation of mineralocorticoids.
D. ITS hypersecreation causes bronze-like pigmentation of skin.

Answer

To determine which statement regarding ACTH (Adrenocorticotropic hormone) is not correct, let's analyze each option step by step:

1. **ACTH is secreted by the anterior lobe of the pituitary gland.**
- This statement is correct. ACTH is indeed produced and secreted by the anterior pituitary gland.

2. **ACTH regulates skin pigmentation in humans.**
- This statement is also correct. ACTH can influence skin pigmentation by stimulating the production of melanin, although its primary role is not pigmentation.

3. **ACTH acts on the adrenal cortex and mainly stimulates the secretion of mineralocorticoids.**
- This statement is incorrect. ACTH primarily stimulates the secretion of glucocorticoids (like cortisol) from the adrenal cortex, not mineralocorticoids (which are primarily regulated by other hormones such as aldosterone).

4. **Hypersecretion of ACTH causes bronze-like pigmentation of the skin.**
- This statement is correct. Excessive levels of ACTH can lead to increased melanin production, resulting in a bronze-like pigmentation of the skin.

Based on this analysis, the statement that is not correct regarding ACTH is:

**ACTH acts on the adrenal cortex and mainly stimulates the secretion of mineralocorticoids.**