Splitting of centrometer of a chromosome during cells division occurs in

Options

A. Metaphase
B. Anaphase
C. Prophase
D. Telophase

Answer

To solve the question regarding the splitting of the centromere of a chromosome during cell division, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Cell Division**: Cell division occurs through two main processes: mitosis and meiosis. Both processes involve several phases.

2. **Identifying the Phases of Mitosis**: Mitosis consists of four main phases:
- Prophase
- Metaphase
- Anaphase
- Telophase

3. **Analyzing Each Phase**:
- **Prophase**: During this phase, chromosomes condense and become visible. The centromeres are present, but they do not split at this stage.
- **Metaphase**: Chromosomes align at the metaphase plate, and spindle fibers attach to the centromeres. There is still no splitting of centromeres.
- **Anaphase**: This is the critical phase where the centromeres split. The spindle fibers pull the sister chromatids apart towards opposite poles of the cell. This is where the actual separation of centromeres occurs.
- **Telophase**: The separated chromatids reach the poles, and the cell begins to divide. The chromosomes start to de-condense back into chromatin, but the centromeres have already split in the previous phase.

4. **Conclusion**: The splitting of the centromere occurs specifically during the **Anaphase** of cell division.

### Final Answer:
The splitting of the centromere of a chromosome during cell division occurs in **Anaphase**.

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