The correct order of sedimentation of subcellular structures during differential centrifugation is

Options

A. Lysosomes `rarr` Mitochondria `rarr` Nucleus `rarr` Ribosome
B. Nucleus `rarr` Mitochondria `rarr` Lysosomes `rarr` Ribosome
C. Mitochondria `rarr` Nucleus `rarr` Lysosomes `rarr` Ribosome
D. Ribosome `rarr` Mitochondria `rarr` Nucleus `rarr` Lysosomes

Answer

To solve the question regarding the correct order of sedimentation of subcellular structures during differential centrifugation, we need to understand the principle behind differential centrifugation and the relative sizes of the organelles involved.

### Step-by-Step Solution:

1. **Understanding Differential Centrifugation**:
- Differential centrifugation is a technique used to separate cellular components based on their size and density. When a sample is centrifuged, larger and denser particles sediment (settle) faster than smaller and less dense ones.

2. **Identifying Subcellular Structures**:
- The subcellular structures mentioned in the question are:
- Nucleus
- Mitochondria
- Lysosomes
- Ribosomes

3. **Determining Size Order**:
- To determine the correct order of sedimentation, we need to arrange these organelles from the largest to the smallest based on their size:
- **Ribosomes**: These are the smallest among the listed organelles and are involved in protein synthesis.
- **Lysosomes**: These are slightly larger than ribosomes and contain enzymes for digestion.
- **Mitochondria**: These are larger than lysosomes and are responsible for energy production.
- **Nucleus**: This is the largest organelle, containing the cell's genetic material.

4. **Correct Order of Sedimentation**:
- Based on the sizes identified, the correct order of sedimentation during differential centrifugation from largest to smallest is:
- Nucleus > Mitochondria > Lysosomes > Ribosomes

5. **Conclusion**:
- Therefore, the correct order of sedimentation of subcellular structures during differential centrifugation is:
- **Nucleus > Mitochondria > Lysosomes > Ribosomes**.