Which cells are mainly responsible for humoral immunity ?

Options

A. Monocytes
B. NK cell
C. T -cells
D. B - cells

Answer

To answer the question, "Which cells are mainly responsible for humoral immunity?", we can break down the information as follows:

### Step-by-Step Solution:

1. **Understand Humoral Immunity**:
- Humoral immunity is a type of immune response that involves the production of antibodies by specific cells in the body. These antibodies are proteins that can bind to foreign antigens (substances that provoke an immune response) and help neutralize or eliminate them.

2. **Identify Key Immune Cells**:
- The main cells involved in humoral immunity are B-cells. These are a type of lymphocyte that plays a crucial role in the adaptive immune response.

3. **Role of B-cells**:
- B-cells are activated when they encounter a specific antigen. Once activated, they differentiate into plasma cells, which are responsible for producing antibodies. These antibodies circulate in the bloodstream and lymphatic system, targeting and neutralizing pathogens.

4. **Interaction with T-cells**:
- T-cells, specifically helper T-cells, play a supportive role in humoral immunity by activating B-cells. They release signaling molecules (cytokines) that stimulate B-cells to proliferate and produce antibodies.

5. **Conclusion**:
- The cells mainly responsible for humoral immunity are B-cells, as they produce antibodies that target and eliminate foreign antigens.

### Final Answer:
The cells mainly responsible for humoral immunity are **B-cells**.