Which of the following is a quantitative diseases caused due to mutation of chromosome 11?

Options

A. Sickle - cell anemia
B. Phenylketonuria
C. Alpha thalassemia
D. Beta thalassemia

Answer

To solve the question "Which of the following is a quantitative disease caused due to mutation of chromosome 11?", we will analyze each option provided.

### Step-by-Step Solution:

1. **Identify the Diseases Listed**: The options given are:
- Option 1: Sickle Cell Anemia
- Option 2: Phenylketonuria
- Option 3: Alpha Thalassemia
- Option 4: Beta Thalassemia

2. **Determine the Chromosomal Mutation**:
- **Sickle Cell Anemia**: Caused by a mutation in the beta-globin gene located on chromosome 11.
- **Phenylketonuria**: Caused by a mutation in the PAH gene, which is not located on chromosome 11.
- **Alpha Thalassemia**: Caused by mutations on chromosome 16, not chromosome 11.
- **Beta Thalassemia**: Caused by mutations in the beta-globin gene, which is also located on chromosome 11.

3. **Classify the Diseases**:
- **Sickle Cell Anemia**: This is a qualitative disease because it results from the synthesis of an abnormal form of hemoglobin (HbS).
- **Phenylketonuria**: This is a metabolic disorder but is not classified as quantitative or qualitative in the same context as the others.
- **Alpha Thalassemia**: This is a quantitative disease, but it is not caused by a mutation on chromosome 11.
- **Beta Thalassemia**: This is a quantitative disease characterized by reduced synthesis of beta-globin chains due to mutations on chromosome 11.

4. **Conclusion**: Based on the classification and the location of the mutations, the disease that is both quantitative and caused by a mutation on chromosome 11 is **Beta Thalassemia**.

### Final Answer:
**Beta Thalassemia** is the quantitative disease caused due to mutation of chromosome 11.

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