Which of the following condition with be observed in a person suffering from sickle cell anemia ?

Options

A. `{:(DNA,mRNA,"Amino acid at " 6^(th)" Position of " beta" chain" ),(CTC,GAG,"Valine"):}`
B. `{:(DNA,mRNA,"Amino acid at " 6^(th)" Position of " beta" chain" ),(CAC,GUG,"Glutamic acid"):}`
C. `{:(DNA,mRNA,"Amino acid at " 6^(th)" Position of " beta" chain" ),(CTC,GAG,"Glutamic acid"):}`
D. `{:(DNA,mRNA,"Amino acid at " 6^(th)" Position of " beta" chain" ),(CAC,GUG," Valine"):}`

Answer

To solve the question regarding the conditions observed in a person suffering from sickle cell anemia, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Sickle Cell Anemia**:
- Sickle cell anemia is a genetic disorder caused by a mutation in the hemoglobin gene. It is characterized by the production of abnormal hemoglobin known as hemoglobin S (HbS).

2. **Identifying the Mutation**:
- The mutation in sickle cell anemia is a point mutation where a single nucleotide in the DNA sequence is changed. Specifically, the adenine (A) replaces thymine (T) in the DNA sequence.

3. **Effects of the Mutation**:
- This mutation leads to the substitution of the amino acid glutamic acid (normally coded by the codon GAG) with valine (coded by the codon GUG) at the sixth position of the beta-globin chain of hemoglobin.

4. **Consequences on Red Blood Cells (RBCs)**:
- The abnormal hemoglobin causes red blood cells to become rigid and take on a sickle or crescent shape, rather than the normal bi-concave disc shape. This change affects the flexibility and lifespan of the RBCs.

5. **Clinical Manifestations**:
- The sickle-shaped cells can block blood vessels, leading to pain crises, increased risk of infections, and other complications such as anemia due to the shorter lifespan of sickle cells.

6. **Conclusion**:
- Therefore, the conditions observed in a person suffering from sickle cell anemia include sickle-shaped red blood cells, increased risk of vaso-occlusive crises, and chronic hemolytic anemia.

### Final Answer:
The answer to the question is that a person suffering from sickle cell anemia will exhibit sickle-shaped red blood cells and related complications.

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