The activity of a certain protein is dependent on its phosphorylation. A mutation in its gene changed a single amino acid which affected the function of the molecule. Which amino acid change is most likely to account for this observation ?

Options

A. Tyrosine to Tryptophan
B. Lysine to valine
C. Leucine to isoleucine
D. Valine to alanine

Answer

A

Explanation

Serine, tyrosine, threonine and histidine are most common target for phosphorylation in eukaryotes.
If Tyrosine get mutated in tryptophan than phosphorylation of gene does not occur and gene can not ne activated