Enzyme X catalyzes hydrolysis of GTP into GDP. The GTP-bound form of X transmits a signal that leads to cell proliferation. The GDP-bound form does transmit any such signal. Mutations in X are found in many cancers. Which of the following alterations of X are most likely to contribute to cancer ?

Options

A. Mutations that increase the of X for GDP
B. Mutations that decrease the affinity of X for GTP
C. Mutations that decrease the rate of GTP hydrolysis
D. Mutations that prevent expression of enzyme X.

Answer

C

Explanation

`"GTP-X Complex"to"Active cell division"`
`"GDP-X Complex"to"No cell division"`
`and GTPunderset("X enzyme")overset("Hydrolysis")toGDP`
Mutation cause the decrease of rate of hydrolysis of GTP. Thus GTP-X complex remain present for long time cell division become uncontrolled.